This city at the foot of the Alps, which was founded by Etruscans in 600 B.C. and conquered by the Romans in 222 A.D., is more than just the main city of Lombardy. The second largest city in Italy after Rome is one of the world's leading commercial and financial centers. The AC Milan and FC Internazionale play in the first division and at times in the European Champions League. The Milan opera, La Scala, is located in a classical 18th century building and enjoys worldwide renown. Several historical buildings can be found in the city center. The most important of these is the Italy's largest Gothic cathedral, which took nearly 200 years to build starting in 1375 and holds 40,000 people. Close by is Milan's shopping district with its famous fashion designers and cozy cafés.